The story revolves around four brothers under a curse that their family will get destroyed if any of them gets married. However, situations change when the eldest brother accidentally marries Seetha.
In this full episode of Rama Sakkani Seetha, Devaraju, the village head's wrong judgment leads to Tulsi committing suicide. Tulsi’s grandfather, the temple priest, curses Devaraju’s family. To escape the curse, the next generation of sons, Ramaraju and his three brothers, vow to never marry.